Functional expression of a vertebrate inwardly rectifying K+ channel in yeast.
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چکیده
منابع مشابه
Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel.
To identify novel potassium channel genes expressed in the retina, we screened a human retina cDNA library with an EST sequence showing partial homology to inwardly rectifying potassium (Kir) channel genes. The isolated cDNA yielded a 2,961-base pair sequence with the predicted open reading frame showing strong homology to the rat Kir2. 4 (rKir2.4). Northern analysis of mRNA from human and bovi...
متن کاملPregnenolone Sulfate Potentiates the Inwardly Rectifying K+ Channel Kir2.3
BACKGROUND Neurosteroids have various physiological and neuropsychopharmacological effects. In addition to the genomic effects of steroids, some neurosteroids modulate several neurotransmitter receptors and channels, such as N-methyl-D-aspartate receptors, gamma-aminobutyric acid type A (GABA(A)) receptors, and sigma(1) receptors, and voltage-gated Ca(2+) and K(+) channels. However, the molecul...
متن کاملAn inwardly rectifying K+ channel is required for patterning.
Mutations that disrupt function of the human inwardly rectifying potassium channel KIR2.1 are associated with the craniofacial and digital defects of Andersen-Tawil Syndrome, but the contribution of Kir channels to development is undefined. Deletion of mouse Kir2.1 also causes cleft palate and digital defects. These defects are strikingly similar to phenotypes that result from disrupted TGFβ/BM...
متن کاملFunctional expression of a Kir2.1-like inwardly rectifying potassium channel in mouse mammary secretory cells.
K(+) channels in mammary secretory (MS) cells are believed to play a role in transcellular electrolyte transport and thus determining ionic composition of the aqueous phase of milk. However, direct evidence for specific K(+) channel activity in native MS cells is lacking at the single-cell level. Here, we show for the first time that an inwardly rectifying K(+) (Kir) channel is functionally exp...
متن کاملExpression of an inwardly rectifying K+ channel, Kir4.1, in satellite cells of rat cochlear ganglia.
Satellite cells are glial cells wrapped around somata of sensory and autonomic ganglion neurons. Neither their functional roles nor electrical properties have been fully clarified so far. Using immunohistochemistry, we found that inwardly rectifying K+ channel subunit Kir4.1 (also called Kir1.2 or KAB-2) was expressed prominently in the satellite cells of cochlear ganglia. The Kir4.1 immunoreac...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1995
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.6.9.1231